| Scientific Name | Author/s | Common Name | Last Record | Distribution | Status | Taxon Profile |
| Alasmidonta mccordi | Athearn, 1964 | Coosa elktoe | pre-1965 | Coosa River, St. Clair County, Alabama, USA | Extinct | Access |
| Alasmidonta robusta | Clarke, 1981 | Carolina elktoe | 1800's | Long Creek, Mecklenburg County, North Carolina, USA | Extinct | Access |
| Alasmidonta wrightiana | (Walker, 1901) | Ochlockonee arcmussel | 1931 | Ochlockonee River, Florida, USA | Extinct | Access |
| Alasmidonta sp. nov. 'Etowah River' | - | - | ? | Etowah River, Georgia, USA | Extinct | Access |
| Anodonta dejecta | Lewis, 1875 | Woebegone floater | 1922? | California, USA | Invalid (synonym) | Access |
| Coelatura rothschildi | (Neuville & Anthony, 1906) | - | 1980's | Lake Turkana, Kenya (northern) | Extinct | Access |
| Contradens fultoni | Haas, 1930 | - | ? | Việt Nam (Vietnam) | Extinct | Access |
| Cuneopsis demangei | Haas, 1929 | - | 1929 | Da River, Phu Tho Province, Việt Nam (Vietnam) | Extinct | Access |
| Fusconaia apalachicola | Williams & Fradkin, 1999 | Apalachicola ebonyshell | c.1350 AD | Alabama, Florida & Georia, USA | Extinct | Access |
| Elliptio nigella | (I. Lea, 1852) | Recovery pearly mussel, Winged spike | (rediscovered) | Apalachicola river system, Georgia, USA | Rediscovered | Access |
| Epioblasma arcaeformis | (I. Lea, 1831) | Arc-form pearly mussel, Sugarspoon | c.1940 | Alabama, Kentucky & Tennessee, USA | Extinct | Access |
| Epioblasma biemarginata | (I. Lea, 1857) | Angled riffleshell | 1970 | Alabama, Kentucky & Tennessee, USA | Extinct | Access |
| Epioblasma cincinnatiensis | I. Lea, 1840 | Cincinnati riffleshell, Ohio riffleshell | 50-90 years ago | Illinois, Indiana, Kentucky, Ohio & Tennessee, USA | Extinct | Access |
| Epioblasma curtisii | Frierson and Utterback, 1916 | Curtis pearlymussel, Curtis' pearlymussel | 1990 (1994?) | Arkansas & Missouri, USA | Extinct | Access |
| Epioblasma flexuosa | (Rafinesque, 1820) | Arcuate Pearly Mussel, Leafshell, Northern Leafshell | 1900 | Alabama, Illinois, Indiana, Kentucky, Ohio & Tennessee, USA | Extinct | Access |
| Epioblasma florentina | (I. Lea, 1857) | Yellow blossom (pearly mussel) | ? | Alabama, Kentucky, Tennessee & Virginia, USA | Extinct | Access |
| Epioblasma gubernaculum | (Reeve, 1865) | Green blossom pearly mussel, Green riffle shell | 1984 | Tennessee & Virginia, USA | Extinct | Access |
| Epioblasma haysiana | (I. Lea, 1834) | Acorn pearly mussel, Acornshell | 1970's | Alabama, Kentucky, Tennessee & Virginia, USA | Extinct | Access |
| Epioblasma lenior | (I. Lea, 1842) | Narrow catspaw, Stone's pearly mussel | 1965 | Alabama & Tennessee, USA | Extinct | Access |
| Epioblasma lewisii | (Walker, 1910) | Lewis’ pearly mussel, Forkshell | pre-1960 | Alabama, Kentucky & Tennessee, USA | Extinct | Access |
| Epioblasma metastriata | (Conrad, 1838) | Upland combshell | 1988 | Alabama, Georgia & Tennessee, USA | Extinct | Access |
| Epioblasma obliquata | (Rafinesque, 1820) | Purple cat's paw pearlymussel | (rediscovered) | USA | Rediscovered | Access |
| Epioblasma othcaloogensis | (I. Lea, 1857) | Southern acornshell, Southern acorn riffle shell | 1974 | Alabama, Georgia & Tennessee, USA | Extinct | Access |
| Epioblasma perobliqua | (Conrad, 1836) | White catspaw, White cat's paw pearly mussel | 1993 | Illinois, Indiana, Kentucky, Michigan & Ohio, USA | Extinct | Access |
| Epioblasma personata | Say, 1829 | Fine-rayed pearly mussel, Round snuffbox, Round combshell | 1924 | Illinois, Indiana, Kentucky, [Oklahoma?] & Ohio, USA | Extinct | Access |
| Epioblasma propinqua | (I. Lea, 1857) | Nearby pearly mussel, Tennessee riffleshell | 1901 | Alabama, Illinois, Indiana, Kentucky, Ohio & Tennessee, USA | Extinct | Access |
| Epioblasma sampsonii | I. Lea, 1861 | Sampson's naiad, Sampson's pearly mussel, Sampson's riffleshell, Wabash riffleshell | pre-1950 | Illinois, Indiana & Kentucky, USA | Extinct | Access |
| Epioblasma stewardsonii | (Lea, 1852) | Cumberland leafshell, Steward's pearlymussel | ? | Alabama, Kentucky & Tennessee, USA | Extinct | Access |
| Epioblasma torulosa | (Rafinesque, 1820) | Tubercled Blossom (pearly mussel), Turberculed riffle shell | ? | Alabama, Illinois, Indiana, Kentucky, Ohio & Tennessee, USA | Extinct | Access |
| Epioblasma turgidula | Lea, 1858 | Turgid blossom, Turgid blossom pearly mussel, Turgid riffleshell, Turgid-blossom naiad | ? | Alabama, Arkansas & Tennessee, USA | Extinct | Access |
| Fusconaia mitchelli | (Simpson, 1895) | False spike | (rediscovered) | Texas, USA | Rediscovered | Access |
| Lamprotula blaisei | Dautzenberg & Fischer, 1905 | - | pre-1982 | Việt Nam (Vietnam) | Extinct | Access |
| Lamprotula crassa | Wood, 1815 | - | 1990's | Bang River, Cao Bang Province, Việt Nam (Vietnam) (northern) | Extinct | Access |
| Lamprotula liedtkei | Rolle, 1904 | - | ? | Việt Nam (Vietnam) (northern) | Extinct | Access |
| Lamprotula nodulosa | Wood, 1815 | - | ? | Việt Nam (Vietnam) (northern) | Extinct | Access |
| Lamprotula triclava | (Heude, 1877) | - | ? | China | Extinct | Access |
| Lampsilis binominata | Simpson, 1900 | Lined pocketbook | c.1973 | Alabama & Georgia, USA | Extinct | Access |
| Medionidus mcglameriae | van der Schalie, 1939 | Tombigbee moccasinshell | ? | USA | Invalid (synonym) | Access |
| Medionidus walkeri | (Wright, 1897) | Suwannee moccasinshell | (rediscovered) | Suwannee River basin, USA (southeastern) | Rediscovered | Access |
| Nodularia cariei | (Germain, 1919) | - | ? | "Mascarene Islands" | Invalid (synonym) | Access |
| Obovaria haddletoni | (Athearn, 1964) | Choctawhatchee pocketbook, Haddleton lampmussel | c.1970 (pre-1982) | Choctawhatchee River, Dale County, Alabama, USA | Extinct | Access |
| Plethobasus cicatricosus | (Say, 1829) | White warty-back pearly mussel, White wartyback | 1982 | Tennessee, USA | Extinct? | Access |
| Pleurobema altum | (Conrad, 1854) | Highnut | pre-1996 | Alabama & Georgia, USA | Invalid (nomen nudum) | Access |
| Pleurobema avellanum | Simpson, 1900 | Hazel pigtoe | ? | Alabama, USA | Invalid (synonym) | Acess |
| Pleurobema bournianum | I. Lea, 1840 | Scioto pigtoe | ? | Ohio, USA | Invalid (synonym) | Access |
| Pleurobema chattanoogaense | (Lea, 1858) | Painted clubshell | (rediscovered) | Coosa River, USA (southeastern) | Invalid (synonym) | Access |
| Pleurobema curtum | (I. Lea, 1859) | Black clubshell, Curtus's mussel | mid-1980's or 1990 | Alabama & Mississippi, USA | Extinct | Access |
| Pleurobema fibuloides | (Lea, 1859) | Kusha pigtoe | pre-1996 | Alabama & Georgia, USA | Extinct | Access |
| Pleurobema flavidulum | I. Lea, 1861 | Yellow pigtoe | ? | Alabama, USA | Extinct | Access |
| Pleurobema hagleri | (Frierson, 1900) | Brown pigtoe | ? | Alabama, USA | Invalid (synonym) | Access |
| Pleurobema hanleyianum | (Lea, 1852) | Georgia pigtoe | (rediscovered) | Coosa River, USA (southeastern) | Rediscovered | Access |
| Pleurobema hartmanianum | (I. Lea, 1860) | Cherokee pigtoe | (rediscovered) | Coosa River, USA (southeastern) | Rediscovered | Access |
| Pleurobema johannis | I. Lea, 1859 | Alabama pigtoe | ? | Alabama, USA | Invalid (synonym) | Access |
| Pleurobema marshalli | Frierson, 1927 | Flat pigtoe, Marshall's mussel | 1980 | Alabama & Mississippi, USA | Extinct | Access |
| Pleurobema murrayense | (Lea, 1868) | Coosa pigtoe | ? | USA | Invalid (synonym) | Access |
| Pleurobema nucleopsis | Conrad, 1849 | Longnut | ? | Alabama & Georgia, USA | Extinct | Access |
| Pleurobema perovatum | Conrad, 1834 | Ovate clubshell | ? | Alabama, Georgia & Mississippi, USA | Extinct | Access |
| Pleurobema rubellum | (Conrad, 1834) | Warrior pigtoe | (rediscovered) | USA | Rediscovered | Access |
| Pleurobema stabile | (Lea, 1861) | Coosa pigtoe | (rediscovered) | Coosa River, USA (southeastern) | Rediscovered | Access |
| Pleurobema troschelianum | I. Lea, 1852 | Alabama clubshell | (rediscovered) | Alabama, Georgia & Tennesse, USA | Rediscovered | Access |
| Pleurobema verum | (I. Lea, 1861) | True pigtoe | ? | Alabama, USA | Extinct | Access |
| Pseudobaphia sp. nov. 'Việt Nam (Vietnam)' | - | - | ? | Việt Nam (Vietnam) | Extinct | Access |
| Quadrula couchiana | (Lea, 1860) | Rio Grande monkeyface | 1898 | Texas, USA | Extinct | Access |
| Theliderma stapes | (I. Lea, 1831) | Stirrupshell, Stirrup shell | 1984 or later | Alabama & Mississippi, USA | Extinct | Access |
| Theliderma tuberosa | (Lea, 1840) | - | ? | USA | Extinct | Access |
| Unio madagascariensis | Sganzin, 1841 | - | pre-1842 | Madagascar (eastern) | nomen dubium | Access |
| Unio malgachensis | Germain, 1911 | - | 1908-1909 | Madagascar | nomen dubium | Access |
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